IndraLab

Statements

BAP1 activates cell growth. 10 / 10
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"In mesothelioma pathogenesis, BAP1 dysfunction contributes to altered cellular growth, enhanced survival, and resistance to apoptosis."
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"In cutaneous melanoma cell lines, however, stable over-expression of BAP1 promoted cell growth while knockdown of BAP1 suppressed cell proliferation with concomitant decrease of survivin, an anti-apoptotic protein [17]."
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"In a previous report, BAP1 increased cell growth, whereas abnormal activity of BAP1 inhibited cell growth in several cancers."
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"The slight upregulation of MYCN protein level in BPA1 overexpressed NB cells and other substrates of BAP1 which exert predominant function in the BAP1 overexpression setting might be the underlying mechanisms for BAP1 expression-induced cell growth retardation."
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"It was reported that depletion of BAP1 in cells with normal expression level of BAP1 could decrease the cell growth and lead to a delayed G1 to S1 transition [34]."
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"Although BAP1 is a tumor suppressor when overexpressed, the knockdown of BAP1 in wild-type UM cells also suppressed cell growth and invasiveness ( Matatall et al., 2013 )."
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"Depletion of BAP1 inhibits neuroblastoma cell growth."
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"In this study, we showed that BAP1 knockdown decreased DNA synthesis, the number of S-phase cells and cell growth in HCC1806 cells."
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"Furthermore, BAP1 knockout in clear cell renal cell carcinoma (ccRCC) inhibits cell growth and migration and promotes the mesenchymal-epithelial transition (MET) partially by downregulating Snail and reducing Rho family GTPases activity [40]."
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"When KLF5 is depleted, BAP1 failed to promote cell growth (XREF_SUPPLEMENTARY)."
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