IndraLab

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USP22 deubiquitinates ADAM9. 3 / 3
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"Here, we found a higher expression of USP22 in PE samples, and USP22 induced the deubiquitination of ADAM9 in trophoblast cells to promote cell dysfunction during PE process."

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"Mechanistically, the deubiquitinase USP22 deubiquitinated ADAM9 and stabilized its expression in trophoblast cells."

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"ADAM9 is highly expressed in PE, and functionally, ADAM9 is deubiquitinated by USP22 to suppress the proliferation, migration, and invasion of trophoblasts [33]."