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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNMA1 binds heme. 2 / 2

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"Although CO still potentiates the activity of the heme bound Slo1 BK Ca channel at a higher Ca 2+ concentration (10 muM) by binding to heme XREF_BIBR - XREF_BIBR, CO actually stimulates the hemin-insensitive H616R mutant in the presence of 336 nM Ca 2 +62."

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"The high affinity binding of heme to Slo1 decreases the frequency of channel opening leading to an inhibition of transmembrane K+ currents[44, 45]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...