IndraLab

Statements

Heme binds KCNMA1. 3 / 3
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"The high affinity binding of heme to Slo1 decreases the frequency of channel opening leading to an inhibition of transmembrane K+ currents[44, 45]."
27923065
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"Although CO still potentiates the activity of the heme bound Slo1 BK Ca channel at a higher Ca 2+ concentration (10 muM) by binding to heme XREF_BIBR - XREF_BIBR, CO actually stimulates the hemin-insensitive H616R mutant in the presence of 336 nM Ca 2 +62."
28474046
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"The same motif is present in cytochrome c [44,45,46]; however, despite this, the mechanisms of heme-binding within the BK channel and cytochrome c are slightly different."
36362175