IndraLab

Statements


| 11

sparser
"The negative charge of Lipoid E80 applied in this CAM-Lip formulation might, in combination with the positive charge of the CS-hydrogel, also cause an interaction between the polymer chains of the gel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"Drug release from different vehicles (CS-CAM, CS-CAM-Lip and CAM-Lip) and further permeation through the pig skin, were investigated using Franz diffusion cells (PermeGear, Bethlehem, USA) with a 5 ml[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"However, the CS-CAM-Lip only enhanced the penetration of CAM as compared to the CAM-Lip formulation (two-tailed t -test, p < 0.05), and showed a higher retention of CAM on the skin surface than the CS[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"The total drug recovery was found to be good and of the same magnitude for all the formulations; 95.37 ± 4.61%, 93.84 ± 3.27%, 96.52 ± 5.71 and 94.26 ± 5.39%, for the CAM-Sol, CAM-Lip, CS-CAM and CS-C[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"The observed sustained release from our CAM-Lip formulation could, however, according to Hurler et al. (2013) , theoretically have been increased by changing the lipid composition of the liposome carr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"When comparing the amount of drug remaining on the skin surface after 8 h from the different formulations; 69.76 ± 4.83%, 55.29 ± 4.04%, 44.15 ± 5.50% and 48.86 ± 2.37%, for the CAM-Sol, CAM-Lip, CS-C[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"However, the negative charge of CAM-Lip could also influence the permeation of CAM through the pig skin, as mentioned in Section 3.1 ."

sparser
"It appears that all the test formulations (CAM-Lip, CS-CAM, CS-CAM-Lip), although acting as the penetration enhancers for CAM, also serve to increase the drug concentration in the skin."

sparser
"Based on the determined MIC-values ( Table 3 ), and the typically applied CAM concentrations in the marketed product, (0.5% or 1%), the CAM-Lip formulations were tested for their antibiotic activity a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"Only small differences between the diameter of the inhibition zones were observed between the CAM-Lip and CAM-Sol formulations ( Table 4 ), and only for the 750 mg/ml CAM-concentration samples, a sign[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"The results in Fig. 1 also indicate decreased skin permeation of CAM from liposome dispersion (CAM-Lip), compared to the hydrogel formulation with unentrapped CAM (CS-CAM) after 8 h."