IndraLab

Statements

ATM phosphorylates UCHL3 on S75. 7 / 7
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sparser
"During DNA damage, UCHL3 is phosphorylated at Ser75 by ATM."
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signor
"The deubiquitinase UCHL3 is phosphorylated and activated by ATM. UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2. |Mutation of S75 (S75A) abolished the pSQ/TQ signal, suggesting that S75 is a major ATM phosphorylation site following DNA damage"
27941124
sparser
"Upon DNA damage, UCHL3 is phosphorylated by ATM at Ser75, the physiological phosphorylation site for ATM, which increases deubiquitinating activity of UCHL3, whereas S75A mutation has no effect on basal activity of UCHL3."
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sparser
"Interestingly, during the DNA damage repair process, Ser75 in UCHL3 can be phosphorylated by ATM, which either enhances its deubiquitinase activity or promotes its degradation [ xref , xref ]."
40691601
sparser
"Upon DNA damage, the DDR signaling is activated, wherein ATM kinase phosphorylates UCHL3 at Ser75 to enhance its deubiquitinase activity."
40691601
biopax:phosphositeplus
No evidence text available
sparser
"Upon persistent DNA damage, the ATM kinase is activated and phosphorylates UCHL3 at Ser75."
40691601