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USP22 activates AKT1. 2 / 3
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"We found that USP22 promotes multidrug resistance in HCC cells by activating SIRT1/protein kinase B (Akt)/multidrug resistance-associated protein 1 (MRP1) pathway, while inhibition of USP22 and SIRT1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Activation of ERK1/2 kinase rather than AKT1 by USP22 was found to be one of the mechanisms promoting LC3 processing."