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OTUD4 inhibits TLR. 2 / 2

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"Meanwhile, the deubiquitinases CYLD and OTUD4 have been revealed as able to cleave K63-linked polyubiquitination of MyD88 and thus to deactivate TLR-mediated NF-κB signaling (11, 12)."

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"Furthermore, studies have shown that DUB ovarian tumor family deubiquitinase 4 (OTUD4) negatively regulates TLR signaling by removing K63-linked ubiquitin chains on MyD88 (68)."

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IndraLab

Statements

OTUD4 inhibits TLR. 2 / 2

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