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Baicalin inhibits NLRP3. 61 / 61
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"Notably, lifestyle interventions like aerobic exercise and dietary supplements, including vitamin D, quercetin, and baicalin, also reduce vascular inflammation via NLRP3 pathways [217,226,227,228,229], emphasizing the importance of integrative approaches in managing this condition.In summary, these preclinical models shed light on key mechanisms, including harmful processes such as oxidative stress, inflammation, and NLRP3 inflammasome activation, as well as protective pathways like the nitrate-nitrite-NO cascade and the SIRT1-eNOS axis."
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"Studies have demonstrated that baicalin could decrease infarct size in MCAO/R rats, suppress the activation of the NLRP3 inflammasome, and inhibit pyroptosis by reducing the expression of pyroptosis-associated proteins (ASC, cleaved caspase-1, IL-1β, and IL-18) (Zheng et al., 2021)."
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"Taken together, these results indicated that baicalin inhibited NLRP3 inflammasome activation in macrophages upon ATP or nigericin stimulation."
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"To further verify that baicalin could inhibit the activation of the NLRP3 inflammasome by suppressing the activation of the PERK/eIF2α pathway in Mtb-infected macrophages, the protein levels of TXNIP were determined by western blotting after PERK siRNA transfection, and TXNIP expression was significantly decreased with this treatment (Figure 6(g))."
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"Baicalin Inhibits NLRP3 Inflammasome Activity Via the AMPK Signaling Pathway to Alleviate Cerebral Ischemia-Reperfusion Injury."
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"Here, we revealed that baicalin could significantly reduce pyroptosis in Mtb-infected macrophages by inhibiting NLRP3 inflammasome activation.Activation of the NLRP3 inflammasome requires two signals, a priming signal and activation signal."
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"Baicalin suppresses the activation of the NLRP3 inflammasome, leading to a decrease in inflammation and the preservation of nerve cells [55]."
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"Altogether, our results revealed that baicalin inhibited NLRP3 inflammasome activation at least partly through augmenting PKA signaling, highlighting its therapeutic potential for the treatment of NLRP3 related inflammatory diseases."
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"Although we had shown that AC inhibitor could reverse baicalin mediated suppression of NLRP3, our data does not exclude the possibility that baicalin may regulate PKA signaling by affecting the activity of PDEs."
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"Consistent with those results, here, we revealed that baicalin also inhibits activation of the PERK/eIF2α pathway and thus downregulates TXNIP expression and subsequently reduces activation of the NLRP3 inflammasome, resulting in reduced pyroptosis in Mtb-infected macrophages (Figure 7)."
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"In a previous study, we have demonstrated that baicalin suppresses reactive oxygen species production, apoptosis, and the NLRP3 and NF-κB signaling pathways during G. parasuis infection of porcine aortic vascular endothelial cells (PAVECs), thus inhibiting G. parasuis-induced inflammation [16]."
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"Together, these results suggested that baicalin suppressed NLRP3 inflammasome activation at least in part through the PKA signaling."
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"Baicalin reduced lipopolysaccharide-induced intestinal inflammatory injury by suppressing the PARP1-mediated NF-κB and NLRP3 signalling pathways [20], alleviated renal fibrosis by inhibiting the PI3K/AKT/NF-κB signalling pathway [21], reduced the inflammatory-oxidative stress effect on H O -induced granulosa cell apoptosis via USP48 protein regulation [22] and provided protection against diethyl nitrosamine-induced liver cirrhosis by suppressing oxidative stress and inflammation [23]."
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"Besides, baicalin has been proven to inhibit the NLRP3 inflammasome signaling, a vital role in neuroinflammation as mentioned above, in APP/PS1 mice [ 19 ] and depression models [ 20 ]."
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"However, whether baicalin suppresses NLRP3 inflammasome activity in PD remains elusive since the pathogenesis of PD is different from Alzheimer's disease and depressive disorder."
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"However, it was unclear whether baicalin could inhibit NLRP3 inflammasome activation at the triggering step (second signal)."
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"For instance, baicalin can reduce ROS production, inhibit p38 MAPK/NF-κB signaling and the NLRP3 inflammasome, and decrease pro-inflammatory cytokines in apolipoprotein E-deficient mice, therefore improving atherosclerosis [110,111]."
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"In this study, we used nigericin stimulation for 1h and found that baicalin significantly inhibited nigericin induced inflammasome activation and cell death in LPS primed macrophages, suggesting that baicalin could inhibit NLRP3 mediated pyroptosis."
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"Altogether, these results suggested that baicalin inhibited NLRP3 inflammasome activation at least partly through augmenting PKA signaling."
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"Instead, baicalin could block NLRP3 inflammasome activation upon ATP or nigericin triggering, indicative of its action on the second signal for this inflammasome."
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"In this study, we found that baicalin markedly inhibited NLRP3 inflammasome activation in LPS primed macrophages upon ATP or nigericin triggering, thereby blocking the activation of caspase-1 and the release of mature IL-1beta and HMGB1."
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"In line with the finding that baicalin inhibited NLRP3 inflammasome activation in vitro, baicalin administration in vivo significantly improved the survival of mice in bacterial sepsis."
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"Baicalin (BA), a natural flavone, reduced hepatic NLRP3 inflammasome components, NLRP3 and caspase-1, which activate interleukins (IL), measured as IL-1."
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"In this study, we found that baicalin robustly suppressed NLRP3 inflammasome activation in LPS primed macrophages upon ATP or nigericin stimulation."
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"In terms of mechanism, the NLRP3 inflammasome and TLRs/NF-κB signaling pathways were down-regulated by baicalin but the Nrf2-HO-1 signaling pathway was up-regulated [ 77 , 81 ]."
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"Results indicate that baicalin suppressed the activation of NLRP3 inflammation and thus alleviated neuroinflammation.We further explored the mechanism of baicalin in the inhibition of NLRP3 inflammaso[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In support of our findings, two separate studies provided evidence that baicalin could suppress the NLRP3 inflammasome pathway in piglet mononuclear phagocytes in response to LPS stimulation or Haemophilus parasuis infection."
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"Baicalin Inhibits NLRP3 Inflammasome Activation in BMDMs."
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"Those previous studies and our data indicated that baicalin robustly inhibited NLRP3 inflammasome activation to attenuate inflammatory responses during infections such as bacterial sepsis."
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"Therefore, apart from its inhibitory effects on NLRP3 transcription as revealed by previous studies, baicalin can also inhibit NLRP3 inflammasome activation in macrophages upon ATP or nigericin triggering."
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"An antidepressant study showed that baicalin can inhibit NLRP3 inflammasomes to reduce IL-1β levels in the prefrontal cortex [ 106 ]."
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"Jin et al. also displayed that Baicalin reduces microglial activation and the number of pro-inflammatory cytokines by inactivating the NLRP3 inflammasome and the TLR4/NF-κB pathway, thus alleviating C[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistent with our previous studies, the results have shown that baicalin could inhibit activation of nuclear factor-kappa B and NLRP3 inflammasome signaling pathways in piglet mononuclear phagocytes and porcine aortic vascular endothelial cells of piglets during G. parasuis infection or LPS stimulation [15,34,35], and protect peritoneal/vascular tight junctions damaged with inhibition of the activation of protein kinase C and myosin light chain kinase/myosin light chain signaling pathway induced by G. parasuis [19,36]."
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"Thus, we conclude that baicalin induced autophagy activation, inhibited the activity of NLRP3 inflammasome through autophagic degradative mechanism, and restrained the secretion of IL-1beta."
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"Baicalin, Probenecid, Amoxicillin, and the Combination of Probenecid and Amoxicillin Attenuated NLR Family Pyrin Domain Containing 3 (NLRP3) Inflammasome Activation in Spleen of G. parasuis-Challenged Mice."
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"The research shows that baicalin at doses of 100 and 200 mg/kg decreases NLRP3 inflammasome and hinders pyroptosis by activating the AMPK signalling pathway both in vivo and in vitro, consequently, alleviating CIRI (Zheng et al., 2021)."
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"The expression of the NLRP3 inflammasome was also increased when the AMPK pathway was blocked by compound C. Taken together, our findings reveal that baicalin reduces the activity of the NLRP3 inflammasome and consequently inhibits cerebral ischemia-reperfusion injury through activation of the AMPK signaling pathway."
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"Furthermore, in our results, baicalin inhibited the activation of NLRP3 inflammasome and thus reduced the inflammatory response in α-syn/MPP + -induced BV2 cells and MPTP mice."
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"Baicalin suppresses the activation of NLRP3 inflammasome."
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"Together, these data further confirmed that baicalin treatment inhibited NLRP3 inflammasome activation through blocking ASC recruitment into the NLRP3 inflammasome."
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"Baicalin inhibited activation of NLRP3 inflammasome in arteries."
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"Collectively, our data demonstrated that baicalin suppressed activation of NLRP3 inflammasome in atherosclerosis mice."
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"Baicalin, with anti-inflammatory activity was shown to inhibit NLRP3 inflammasome in mononuclear phagocytes [23] ."
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"Baicalin suppressed activation of NLRP3 inflammasome by enhancing PKA signaling pathway and ameliorated monosodium urate crystal (MSU)-induced peritonitis [73,74] ."
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"Baicalin Mediated Inhibition of NLRP3 Inflammasome Activation and IL-1beta Release Is Reversed by the PKA Pathway Inhibitors."
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"As mentioned above, NLRP3 inflammasome plays an important role in the pathogenesis of depression, and baicalin is known to inhibit the activation of NLRP3 inflammasome in multiple disease models [7–9][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistent with these studies, we in this study provided evidence that baicalin suppressed NLRP3 activation by modulating PKA activity."
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"Baicalin inhibits pro-inflammatory cytokine release, MAPK activation, NF-κB pathway activation, and NLRP3 to diminish inflammation in periodontal cells."
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"In light of previous findings that the PKA negatively regulates NLRP3 activation and that baicalin may increase the PKA activity, we next explored whether baicalin suppressed the NLRP3 inflammasome activation by upregulating PKA signaling in macrophages."
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"Zhang et al. 32 described that baicalin inhibited Mycobacterium induced activation of NLRP3, which contributed to the increased bacterial killing in macrophage."
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"However, whether baicalin suppresses NLRP3 inflammasome signaling in PD models remains unclear."
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"On the contrary, baicalin treatment could either inhibit the formation of ASC specks in immunofluorescence or decrease the NLRP3, ASC, pro-caspase-1 in a dose dependent manner."
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"This study confirms our assumption: baicalin significantly suppressed the activation of NLRP3 inflammasome in PD models."
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"Baicalin reduced vandetanib induced myocardial injury by regulating redox balance and NLRP3 inflammasome pathway."
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"Moreover, baicalin could inhibit the activation of NF-kappaB and NLRP3 inflammasome signaling pathway triggered by H. parasuis, which was first reported in the anti-inflammatory action during H. parasuis infection."
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"Collectively, these data demonstrated that baicalin can suppress NLRP3 inflammasome activation by, at least partly, modulating PKA signaling."
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"Although baicalin inhibited the activation of NLRP3 inflammasome, the effects of baicalin on the function of PMNP needs further investigation."
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"Taken together, in our study, we demonstrate for the first time that baicalin has an anti-inflammatory activity, and inhibits the NF-kappaB signaling pathway and NLRP3 inflammasome activation in PMNP when infected with H. parasuis."
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"Furthermore, blocking cAMP formation by inhibiting the adenyl cyclase (AC) activity also significantly reversed baicalin induced suppression of NLRP3 activation, highlighting the possibility that baicalin may modulate upstream components of PKA signaling."
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"Baicalin inhibits microglia activation by regulating the NLRP3, AKT1, and S1RT1-NF-κB signaling pathways and consequently alleviates neuroinflammation and depression."
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"These results indicated that baicalin can reduce pyroptosis by inhibiting NLRP3 inflammasome activation.Generally, the NLRP3 inflammasome can be activated by various pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) [14, 15]."
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