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Baicalin inhibits NLRP3. 38 / 38
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"The effect of baicalin on inhibiting the interaction between TXNIP and NLRP3 might be due to suppressing the dissociation of TXNIP and TRX , but the specific mechanism through which baicalin inhibits TXNIP and NLRP3 needs to be further explored ."
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"Although baicalin inhibited the activation of NLRP3 inflammasome, the effects of baicalin on the function of PMNP needs further investigation."
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"In light of previous findings that the PKA negatively regulates NLRP3 activation and that baicalin may increase the PKA activity, we next explored whether baicalin suppressed the NLRP3 inflammasome activation by upregulating PKA signaling in macrophages."
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"Taken together, in our study, we demonstrate for the first time that baicalin has an anti-inflammatory activity, and inhibits the NF-kappaB signaling pathway and NLRP3 inflammasome activation in PMNP when infected with H. parasuis."
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"Together, these data further confirmed that baicalin treatment inhibited NLRP3 inflammasome activation through blocking ASC recruitment into the NLRP3 inflammasome."
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"Taken together, these results indicated that baicalin inhibited NLRP3 inflammasome activation in macrophages upon ATP or nigericin stimulation."
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"Furthermore, blocking cAMP formation by inhibiting the adenyl cyclase (AC) activity also significantly reversed baicalin induced suppression of NLRP3 activation, highlighting the possibility that baicalin may modulate upstream components of PKA signaling."
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"Consistent with those results, here, we revealed that baicalin also inhibits activation of the PERK/eIF2α pathway and thus downregulates TXNIP expression and subsequently reduces activation of the NLRP3 inflammasome, resulting in reduced pyroptosis in Mtb-infected macrophages (Figure 7)."
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"Baicalin could inhibit activation of the PERK/eIF2 α pathway and thus downregulates TXNIP expression and subsequently reduces activation of the NLRP3 inflammasome, resulting in reduced pyroptosis in Mtb-infected macrophages."
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"Together, these results suggested that baicalin suppressed NLRP3 inflammasome activation at least in part through the PKA signaling."
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"Collectively, our data demonstrated that baicalin suppressed activation of NLRP3 inflammasome in atherosclerosis mice."
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"In support of our findings, two separate studies provided evidence that baicalin could suppress the NLRP3 inflammasome pathway in piglet mononuclear phagocytes in response to LPS stimulation or Haemophilus parasuis infection."
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"Collectively, these data demonstrated that baicalin can suppress NLRP3 inflammasome activation by, at least partly, modulating PKA signaling."
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"Altogether, our results revealed that baicalin inhibited NLRP3 inflammasome activation at least partly through augmenting PKA signaling, highlighting its therapeutic potential for the treatment of NLRP3 related inflammatory diseases."
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"Baicalin Inhibits NLRP3 Inflammasome Activity Via the AMPK Signaling Pathway to Alleviate Cerebral Ischemia-Reperfusion Injury."
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"Although we had shown that AC inhibitor could reverse baicalin mediated suppression of NLRP3, our data does not exclude the possibility that baicalin may regulate PKA signaling by affecting the activity of PDEs."
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"Altogether, these results suggested that baicalin inhibited NLRP3 inflammasome activation at least partly through augmenting PKA signaling."
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"Baicalin suppresses the activation of NLRP3 inflammasome."
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"In this study, we used nigericin stimulation for 1h and found that baicalin significantly inhibited nigericin induced inflammasome activation and cell death in LPS primed macrophages, suggesting that baicalin could inhibit NLRP3 mediated pyroptosis."
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"These results indicated that baicalin can reduce pyroptosis by inhibiting NLRP3 inflammasome activation.Generally, the NLRP3 inflammasome can be activated by various pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) [14, 15]."
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"However, it was unclear whether baicalin could inhibit NLRP3 inflammasome activation at the triggering step (second signal)."
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"Therefore, apart from its inhibitory effects on NLRP3 transcription as revealed by previous studies, baicalin can also inhibit NLRP3 inflammasome activation in macrophages upon ATP or nigericin triggering."
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"Baicalin Inhibits NLRP3 Inflammasome Activation in BMDMs."
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"In this study, we found that baicalin markedly inhibited NLRP3 inflammasome activation in LPS primed macrophages upon ATP or nigericin triggering, thereby blocking the activation of caspase-1 and the release of mature IL-1beta and HMGB1."
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"Here, we revealed that baicalin could significantly reduce pyroptosis in Mtb-infected macrophages by inhibiting NLRP3 inflammasome activation.Activation of the NLRP3 inflammasome requires two signals, a priming signal and activation signal."
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"On the contrary, baicalin treatment could either inhibit the formation of ASC specks in immunofluorescence or decrease the NLRP3, ASC, pro-caspase-1 in a dose dependent manner."
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"Baicalin Mediated Inhibition of NLRP3 Inflammasome Activation and IL-1beta Release Is Reversed by the PKA Pathway Inhibitors."
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"Baicalin inhibited activation of NLRP3 inflammasome in arteries."
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"Zhang et al. 32 described that baicalin inhibited Mycobacterium induced activation of NLRP3, which contributed to the increased bacterial killing in macrophage."
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"Thus, we conclude that baicalin induced autophagy activation, inhibited the activity of NLRP3 inflammasome through autophagic degradative mechanism, and restrained the secretion of IL-1beta."
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"To further verify that baicalin could inhibit the activation of the NLRP3 inflammasome by suppressing the activation of the PERK/eIF2α pathway in Mtb-infected macrophages, the protein levels of TXNIP were determined by western blotting after PERK siRNA transfection, and TXNIP expression was significantly decreased with this treatment (Figure 6(g))."
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"Instead, baicalin could block NLRP3 inflammasome activation upon ATP or nigericin triggering, indicative of its action on the second signal for this inflammasome."
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"Moreover, baicalin could inhibit the activation of NF-kappaB and NLRP3 inflammasome signaling pathway triggered by H. parasuis, which was first reported in the anti-inflammatory action during H. parasuis infection."
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"The expression of the NLRP3 inflammasome was also increased when the AMPK pathway was blocked by compound C. Taken together, our findings reveal that baicalin reduces the activity of the NLRP3 inflammasome and consequently inhibits cerebral ischemia-reperfusion injury through activation of the AMPK signaling pathway."
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"In this study, we found that baicalin robustly suppressed NLRP3 inflammasome activation in LPS primed macrophages upon ATP or nigericin stimulation."
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"In line with the finding that baicalin inhibited NLRP3 inflammasome activation in vitro, baicalin administration in vivo significantly improved the survival of mice in bacterial sepsis."
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"Consistent with these studies, we in this study provided evidence that baicalin suppressed NLRP3 activation by modulating PKA activity."
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"Those previous studies and our data indicated that baicalin robustly inhibited NLRP3 inflammasome activation to attenuate inflammatory responses during infections such as bacterial sepsis."
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