IndraLab

Statements

USP22 ubiquitinates CCND1. 3 / 3
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"While the screen confirmed known substrates of USP22, including histones H2A and H2B, the sole component of the core cell cycle machinery identified as a USP22 substrate in this screen was the G1 phase cyclin CCND1.Further analysis of the USP22–CCND1 relationship revealed that USP22 directly reverses polyubiquitylation of CCND1 via a pathway distinct from protein-destabilizing GSK3β phosphorylation and ultimately protects CCND1 from proteasome-mediated degradation (16, 17)."
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"Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells."
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reach
"Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells."
30224477