IndraLab

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"The IC50 for a prochlorperazine block of HERG current in Xenopus oocytes progressively decreased relative to the degree of depolarization, from 42.1 microM at -40 mV to 37.4 microM at 0 mV to 22.6 microM at +40 mV."
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"The block of HERG by prochlorperazine was use dependent, exhibiting a more rapid onset and a greater steady-state block at higher frequencies of activation, while there was partial relief of the block with reduced frequencies."
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"Blockade of HERG human K+ channel and IKr of guinea pig cardiomyocytes by prochlorperazine."
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