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"To address the question of whether HERG channels are also blocked by prochlorperazine in its inactivated state, a long test pulse to + 80 mV (4 s) was applied to inactivate the channels, followed by a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, prochlorperazine inhibits HERG channels predominantly in the open and inactivated state rather than in the closed state.To examine the use-dependence of the prochlorperazine effect, HE[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We also found that a steady-state HERG channel blockade by prochlorperazine was initially obtained with depolarization at 3 s intervals ( Fig. 4 C), and that a subsequent increase of the depolarizatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, we used the HERG channel expressed in Xenopus oocytes to test whether prochlorperazine would block the HERG channel."
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"The IC 50 values for prochlorperazine blockading of the HERG current were 42.1, 37.4, and 22.6 μM at − 40, 0, and + 40 mV, respectively ( n = 9), indicating that the prochlorperazine block of HERG cur[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Additionally, at the beginning of the pulse the fractional sustained current (obtained by normalizing the currents with prochlorperazine relative to control currents) was 0.894 ± 0.062 of the control [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this series of experiments, 20 μM prochlorperazine reduced HERG outward currents at the end of the 0 mV pulse by 51.3 ± 2.1% ( n = 8)."
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"These results indicate that the prochlorperazine blockade of HERG channels is strongly use-dependent.Next, the effect of prochlorperazine on activated currents was tested."
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"To understand the mechanisms underlying prochlorperazine-induced electrophysiological changes in the action potential and ECG, it is important to determine the effects of this drug on each molecular e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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