IndraLab

Statements

HSPA decreases the amount of KCNH2. 4 / 4
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"The upregulation of hERG expression by Kv4.3 is dependent on Hsp70, as Hsp70 siRNA could prevent the Kv4.3-induced hERG expression."
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"Knockdown of HSP70 reduced overall levels of WT hERG, but knockdown of HSC70 increased hERG levels."
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"The results showed that downregulation of Hsp70 using siRNA or VER155008 effectively abolished the elevation of matured hERG protein expression in the cells co-transfected with hERG and Kv4.3."
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"However, although downregulation of Hsp70 decreased hERG protein expression in cells co-transfected with Kv4.3 and hERG, Hsp70 did not play a critical role in the complex formation between hERG and Kv4.3."
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