IndraLab

Statements

YOD1 activates NFkappaB. 4 / 7
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"Potentially, YOD1 could also function as a p97 co-factor for IkappaBalpha degradation to support canonical NF-kappaB signaling, but it is unclear why this would affect signaling in response to some inducers (e.g. CD40) while others are unaffected (e.g. IL-1 and TNF)."
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"However, why and how YOD1 promotes canonical NF-kappaB signaling and activation in the context of p62 independent CD40 or RANK stimulation is currently unclear and we can only speculate."
28244869
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"Whereas knock-down of TRAF6 or p62 severely impaired IL-1beta triggered NF-kappaB activation as evident by EMSA, depletion of YOD1 enhanced NF-kappaB activation (XREF_FIG)."
28244869
reach
"YOD1 is released from TRAF6 upon IL-1 stimulation and YOD1 depletion enhances canonical NF-kappaB activation."
28244869