IndraLab

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USP29 activates CGAS. 3 / 3
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"These data together suggest that USP29 deconjugates K48 linked polyubiquitin chains from cGAS and thereby inhibits the proteasomal degradation of cGAS."
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"In contrast, cGAS was still degraded in Usp29 m/m MLFs (half-life ~ 8h) after HSV-1 infection, which was due to inefficient induction of cGas transcription and accelerated degradation of basal and newly synthesized cGAS caused by the absence of USP29."
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"In addition, we found that TRIM38 and USP29 interacts with cGAS independently, suggesting that TRIM38 mediated sumoylation and USP29 mediated deubiquitination of cGAS cooperatively regulate the stability of cGAS."
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