IndraLab

Statements

OTUB1 increases the amount of CD274. 4 / 4
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"They knocked down different OTU-family DUBs and found OTUB1 knockdown significantly decreases PD-L1 protein levels in breast cancer cells."
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"Functionally, OTUB1 depletion decreases PD-L1 expression, and increases the cytotoxicity of human peripheral blood mononuclear cells against tumor cells."
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"PKP3-mediated OTUB1 upregulation further elevates the expression of PD-L1 by facilitating its deubiquitination.69 Therefore, the regulatory effect possessed by circIGF2BP3 on PKP3/OTUB1/PD-L1 axis may provide a novel mechanism for conquering immune escape in treating NSCLC."
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"Firstly, inhibiting OTUB1 decreases the expression of PD-L1 (Kraehenbuehl et al., 2022)."
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