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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

PSMD14 inhibits TP53BP1. 3 / 3

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"POH1 activity associated with the proteasome results in cleavage of K63 chains at damage sites, and limits the accumulation of 53BP1 at DSBs."

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"Reduced DNA repair in RNF8-, RNF168- or 53BP1 depleted cells, in which no 53BP1 IRIF form, could be countered by co-depletion of POH1, which restored both repair and 53BP1 IRIF."

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"USP44, USP17L2/DUB3, USP11, ZUFSP and POH1 loss promotes the excessive spreading of Ub at DSBs and concomitant excessive accumulation of 53BP1 [57–65]."

31769469

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

PSMD14 inhibits TP53BP1. 3 / 3

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