IndraLab

"TREK-1 is highly expressed in prostate cancer, unlike in healthy prostate or benign prostatic hyperplasia. xref , xref In addition, its expression is strongly correlated with the grade and stage of prostate cancer. xref Overexpression of TREK-1 in healthy prostate epithelial cells increased their proliferation ability. xref In contrast, the knockdown of TREK-1 significantly inhibited the proliferation of prostate cancer cells. xref Recently, an investigation of ion channels and electrogenic proteins in Xenopus oocytes demonstrated that TREK-1 functionally interacts with BVES/POPDC1. xref Co-expression of BVES/ POPDC1 and TREK-1 stimulates a twofold higher current than that measured in the absence of BVES/POPDC1. xref However, the role of BVES/POPDC1–TREK-1 interaction in human cancers has not been examined."