IndraLab

Statements

OTUB1 activates CRC. 4 / 4
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"OTUB1 promotes CRC metastasis by facilitating EMT and acts as a potential distant metastasis marker and prognostic factor in CRC."
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"Subsequent experiments further suggested that OTUB1 promoted CRC malignancy by enhancing protein stability of beta-catenin, via inhibition of its protein degradation by UPP pathway, which indicated its crucial role in enhancement of CRC tumor cellular proliferative and chemo-resistant capabilities."
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"OTUB1 silencing suppressed CRC cancer cell survivability treated with multiple chemo-agents."
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"Moreover, subsequent WB and qRT-PCR test provided intriguing evidences that OTUB1 overexpression also considerably enhanced stem-cell markers of CRC tumor including CD133 and CD44 (Figure 4g-h)."
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