IndraLab

Statements


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sparser
"We previously reported that uncoupling the CaV2.2CRMP2 interaction with TAT- [ xref ] or R9-CBD3 [ xref ] resulted in a reduction of depolarization-induced Ca 2+ -influx in sensory neurons."

sparser
"To determine if perturbing the CRMP-2CaV2.2 interaction with the TAT-CBD3 peptide can modulate transmitter release, resting and potassium-stimulated release of immunoreactive CGRP (iCGRP) was measured from supernatants of DRG neurons in culture that were treated with 10 μM TAT-CBD3 or TAT scramble."

sparser
"We previously reported that uncoupling the CaV2.2CRMP2 interaction with tat-CBD3 resulted in reduction of depolarization-induced Ca 2+ -influx in sensory neurons. xref Here, we asked whether the myr-tat-CBD3 peptide could work similarly."