IndraLab

Statements

YY1 increases the amount of USP13. 3 / 3
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"Together, our findings revealed that YY1 transcriptionally upregulated USP13 expression, indirectly increased WWP1 protein expression and promoted HCC progression."
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"Next, a dual luciferase reporter assay demonstrated that YY1 bound to the AAAAATAGCGTC sequence in motif 3 and activated USP13 transcription."
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"Our results revealed that YY1 depletion in HCC cells led to a decrease in both the mRNA and protein levels of USP13 (Fig. 7B, C) and that YY1 overexpression upregulated USP13 expression (Supplementary Fig. S7C, D)."
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