IndraLab

Statements


Allitridin inhibits KCNH2. 2 / 2
| 2

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"Allitridin does not alter the voltage- and time dependent activation of hERG channels, the gating properties of hERG channel inactivation over time or the recovery from inactivation, but allitridin does cause alterations in the steady-state inactivation and the deactivation of hERG channels."

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"Other reports show that allitridin impairs the trafficking of hERG channels to reduce the IKr current [XREF_BIBR]."