IndraLab

Statements

Forskolin activates KCNQ1. 9 / 9
| 8 1
reach
"Taken together, these results indicate that the main component of the current stimulated by forskolin is generated by KCNQ1 channel activity.Since we have shown that dexamethasone inhibited the ATP-in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31330137
reach
"Treatment with GSK-3 iX decreased the forskolin stimulated KCNQ1 currents."
| PMC
reach
"Forskolin significantly increased the KCNQ1/KCNE1 current density over the entire voltage range from −10 to +110 mV."
37108427
reach
"At +110 mV, forskolin increased the KCNQ1/KCNE1 current density from 644 ± 60 to 839 ± 72 pA/pF.The KCNQ1/KCNE1 current activated with a characteristic time course."
37108427
reach
"Forskolin significantly increased the KCNQ1/KCNE1 current activation rate by ≈40% over the entire voltage range from −10 to +110 mV.The normalized amplitude of the tail current at −60 mV is plotted against the preceding depolarizing test potential in Figure 1C to determine the voltage dependence of the amount of KCNQ1/KCNE1 current activation in the absence and the presence of forskolin."
37108427
sparser
"Since we have shown that dexamethasone inhibited the ATP-induced Cl - secretion and this activated Cl - secretion involved KCNQ1 activity, it was of interest to determine if dexamethasone exerted inhi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31330137
reach
"Forskolin significantly increased the fully-activated conductance of the KCNQ1/KCNE1 current by ≈23%, shifted the half-maximal activation voltage towards more negative potentials by ≈15 mV, and decreased the time constant of current activation by ≈30% (Figure 1)."
37108427
reach
"Forskolin, a specific cAMP agonist, increased KCNQ1 channel currents in a rapid and sustained manner which were inhibited by chromanol 293B, a specific inhibitor of KCNQ1 channels."
31330137
reach
"Results : Forskolin stimulated KCNQ1 currents were measured in untreated cl.19 A monolayers."
| PMC