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Kaempferol inhibits NLRP3. 12 / 12
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"Past studies have shown that the JNK/c-Jun pathway serves crucial roles in the microglial response and kaempferol attenuates retinal ganglion cell death by suppressing the NLRP3 inflammasome through JNK pathways in acute glaucoma (52,53)."
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"Therefore, these compounds suppress NLRP3 activity and IL-1β release independently of their direct effect on any components in the NLRP3 inflammasome.For example, a natural flavanol, Kaempferol degrades NLRP3 through autophagy and ubiquitin related proteolysis which protects dopaminergic neuron loss in PD mice model (Han X. et al., 2019)."
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"They also discussed pre-clinical outcomes of several NLRP3 inflammasome inhibitors (such as MCC950, Kaempferol, and miRNA-7) in treating PD and other neurodegenerative diseases (Su et al.)."
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"Previous researches indicate that quercetin, ginsenoside, and kaempferol extracted from TCM herbs can effectively inhibit the activation of NLRP3 inflammasomes ( Chen et al., 2022 ; Jiang et al., 2022[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, in glaucoma pathology, kaempferol decreased NLRP3 and NLRP1 inflammasome activation, which attenuates retinal ganglion cell death via inhibition of NF-κB and JNK pathways [175]."
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"In addition , withaferin A and kaempferol inhibit NLRP3 via indirect mechanisms ."
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"88 In contrast , kaempferol decreases NLRP3 expression by regulating the autophagy pathway ."
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"It was reported that kaempferol could attenuate retinal ganglion cell death by suppressing the NLRP3 inflammasome through JNK pathways in acute glaucoma ( Lin et al., 2019 )."
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"In the context of APAP-induced hepatotoxicity, research has demonstrated that Kaempferol, a flavonoid molecule, can inhibit the activation of the NLRP3 inflammasome by protecting the liver from inflammation and consequent apoptosis [15] (Table 1)."
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"Additionally, kaempferol treatment significantly inhibited the STING/NLRP3 signaling pathway in adipose tissue."
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"Additionally, kaempferol inhibited activation of the NLRP3/caspase-1 signaling pathways in RAW 264.7 macrophages."
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"In addition, Zhai et al. found that kaempferol could effectively attenuate inflammation and insulin resistance in adipose tissue of db/db mice by regulating the STING/NLRP3 signalling pathway [ 89 ]."
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