IndraLab

Statements

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"It is known that the hERG K + channel can be modulated by cAMP and PKA."
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"Activation of cAMP and PKA increased the abundance of HERG signal in both groups to a comparable degree as in cells transfected with HERG alone with no statistically significant difference."
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"Cyclic AMP may also activate HERG, thereby increasing net out- ward current and accelerating the rate of myocellular repo- larization."
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"Cyclic AMP may also activate HERG, thereby increasing net out- ward current and accelerating the rate of myocellular repo- larization."
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"Although our results were most consistent with cAMP and PKA enhancement of HERG abundance from accelerated synthesis awe sought to carefully examine possible contribution of channel degradation changes."
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"As Kv11.1 channel activity is enhanced by cAMP‐dependent protein kinase A (e.g., Chen et al., 2010) we speculated if Kv11 channels contributed functionally to β‐adrenoceptor‐mediated responses."
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"That the polysome profile shapes are not significantly changed upon kinase stimulation is consistent with our previous observation that cAMP dependent increase of HERG protein was specific and did not alter other proteins we assayed [XREF_BIBR],."
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"3.6 Transcriptional inhibition abrogates the cAMP mediated HERG enhancement."
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"Elevation of cAMP can modulate HERG K+ channels both by direct binding and indirect regulation through protein kinase A. To assess the physiological significance of cAMP binding to HERG, we introduced mutations to disrupt the cyclic nucleotide binding domain."
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"3.8 MiRP (KCNE) proteins in the cAMP and PKA augmentation of HERG."
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