IndraLab

Statements

L-cysteine inhibits NLRP3. 2 / 2
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"Although it can not be distinguished whether BOT-4-one directly promoted NLRP3 ubiquitination or inhibited the deubiquitination process of NLRP3, this PKA independent enhancement of NLRP3 ubiquitination could be due to NLRP3 alkylation, as it was also induced by other NLRP3 alkylators, Bay11-7082 and MNS, and efficiently blocked by L-cysteine."
29118366
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"However, it can be reasonably regarded that the observed enhancement of ubiquitination was attributed to the NLRP3 alkylation, as other known NLRP3 alkylators showed the same functionality and can be commonly inhibited by L-cysteine."
29118366