IndraLab

Statements

eidos
"Antirheumatic chloroquine , and hydroxychloroquine , inhibit CYP2D6 , thus requiring adjusting galantamine and donepezil [ 165 ] ."
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"Later, in vitro evidence showed that HCQ metabolites inhibit CYP3A4 [10]: only in 2023, a detailed in vitro study showed that HCQ is metabolized by CYP2D6, CYP3A4 and CYP2C8, and also suggested that HCQ and its metabolites might inhibit CYP2D6 [10]."
38114885
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"That trial evaluated the interaction of HCQ with metoprolol and dextromethorphan in healthy volunteers and indicated that HCQ weakly inhibits CYP2D6 [12]."
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"[XREF_BIBR XREF_BIBR] Chloroquine and hydroxychloroquine are inhibitors of CYP2D6."
33912505
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"Hydroxychloroquine is metabolized by CYP2D6, CYP3A4, and CYP2C8, and inhibits CYP2D6, while its metabolites also inhibit CYP3A in vitro."
36446607
eidos
"Hydroxychloroquine is metabolized by CYP2D6 , CYP3A4 , and CYP2C8 , and inhibits CYP2D6 , while its metabolites also inhibit CYP3A in vitro ."
36446607
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"In vitro, HCQ and its metabolites, mainly desethylchloroquine, have been reported to competitively and reversibly inhibit CYP2D6 activity, albeit only mildly [10]."
38114885
eidos
"HCQ may also inhibit CYP2D6 , interacting with a variety of different COVID-19 and non-COVID-19 medications ."
| PMC
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"In the only clinical trial on the CYP2D6-inhibiting properties of HCQ so far, CYP2D6-inhibiting properties of HCQ were evaluated after an 8-day course of 400 mg HCQ twice daily in seven healthy volunteers [12]: after administration of HCQ, the AUC of the CYP2D6 substrate metoprolol increased by 65% and C by 72%."
38114885
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"In fact , chloroquine and hydroxychloroquine inhibit CYP2D6 , which metabolizes several antipsychotics , antidepressants , and antihistamines , while ritonavir inhibits CYP3A4 , actively involved in the metabolism of some macrolides , azole antifungals , antidepressants , and antihistamines ."
| PMC
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"18 Chloroquine and hydroxychloroquine also inhibit CYP2D6, which may increase beta-blocker exposure and risk of bradycardia, PR interval prolongation, and atrioventricular block."
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"HCQ appears to inhibit CYP2D6 and can affect the levels of psychotropic medications dependent on CYP2D6 for their metabolism."
32874009
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"Furthermore, CQ and HCQ can inhibit CYP2D6 activity thus suppressing the metabolism of their own and other drugs metabolised by the enzyme."
34104100
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"Hydroxychloroquine and chloroquine inhibit CYP2D6 and may increase plasma concentration of metoprolol 48; a similar effect may be observed in carvedilol but has never been studied."
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"[XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR] Ritonavir as well as hydroxychloroquine increases the effects of tetrabenazine by inhibiting hepatic enzyme CYP2D6 metabolism."
33912505
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"Moreover, chloroquine and hydroxychloroquine are mild inhibitors of CYP2D6, and have potential interactions with numerous psychotropic medications.Tocilizumab’s neuropsychiatric effects have not been widely studied in the context of COVID-19 treatment."
38620912
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"The ability of CQ and HCQ to inhibit CYP2D6 might reduce the analgesic efficacy of opioids which are metabolised by CYP2D6 [123, 124]."
34306523
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"Combined with the fact that HCQ and ritonavir directly inhibit CYP2D6 and CYP3A4 , respectively , there is a potential for QT prolongation culminating in torsades de pointes ( 102 ) ."
| PMC
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"For example, it has been shown that hydroxychloroquine can slightly inhibit CYP2D6 metabolism (in this study, this is important when using haloperidol, risperidone, and aripiprazole), but there were great concerns about the possible prolongation of the QT interval during their interaction [82]."
40005415
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"HCQ appears to inhibit CYP2D6 and can affect the levels of psychotropic medications dependent on CYP2D6 for their metabolism ."
32874009
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"Both CQ and HCQ inhibit CYP2D6 activity through competitive mechanisms."
34028468
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"Furthermore, our findings show that HCQ and its metabolites are inhibitors of CYP2D6, which likely explains the previously observed interaction between HCQ and metoprolol."
36446607
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"Hydroxychloroquine, by inhibiting the CYP2D6, leads to an increase in the serum concentration of beta-blockers."
32921718
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"Both CQ and HCQ were reported to inhibit CYP2D6 activity [ 58 ] ."
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