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"In addition, we showed that the H 2 O 2 levels increased in the hippocampus of the seizure mice, and H 2 O 2 could promote the binding of MDH2 to the binding sites of Scn1a gene, whereas β-mercaptoethanol decreased the binding capability, indicating an important effect of the seizure-induced oxidation on the MDH2-mediated downregulation of Scn1a expression."