IndraLab

Statements

TGFBR binds USP15. 3 / 3
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"USP15 binds to the SMAD7-SMAD-specific E3 ubiquitin protein ligase 2 (SMURF2) complex, and deubiquitylates and stabilizes the type I TGFβ receptor, leading to enhanced TGFβ signalling."
28959952
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"USP15 binds to the SMAD7-SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) complex and deubiquitinates and stabilizes type I TGF-beta receptor (TbetaR-I), leading to an enhanced TGF-beta signal."
22344298
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"Furthermore, co-immunoprecipitation (Co-IP) demonstrated that USP15 could interact with TGF-beta receptor I (TBR1) and promote its deubiquitination, thereby maintaining TGF-beta signalling pathway activity by enhancing TBR1 stability."
30980801