IndraLab

Statements

ZEB1 activates USP7. 3 / 3
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"Zeb1 in turn interacts with and promotes the activity of ubiquitin-specific-processing protease 7 (USP7), which deubiquitinates and stabilizes that serine/threonine kinase checkpoint kinase 1 (CHK1) t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Zhang et al. reported that ZEB1, an EMT inducer, can enhance CHK1 protein stability through regulating USP7, thereby promoting DNA damage repair and radiation resistance in breast cancer cells [ 27 ]."
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"How exactly ZEB1 specifically promotes the interaction of USP7 with CHK1 but not with other USP7 substrates warrants future investigation."
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