IndraLab

Statements

USP38 binds IREB2. 2 / 2
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"USP38 could bind to iron regulatory protein 2 (IRP2), stabilizing it and removing K48-linked polyubiquitination chains, leading to increasing intracellular iron overload, lipid peroxidation, and ultimately contribute to ferroptosis."
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"Mechanistically, USP38 bound to iron regulatory protein 2 (IRP2), stabilizing it and remove K48-linked polyubiquitination chains, thereby increasing intracellular iron overload, lipid peroxidation, and ultimately contributing to ferroptosis."
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