IndraLab

Statements

KRAS binds USP2. 4 / 4
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reach
"Taken together, these results suggest that USP2 may enhance the protein stability of KRAS.Based on the above results, we hypothesized that USP2 may interact with and deubiquitinate KRAS."
39807309
reach
"Endogenous interaction of KRAS and USP2 was further verified in MM.1S cells (Fig. 4J)."
39807309
sparser
"In the present study, we demonstrated that USP2 is a DUB that directly controls KRAS ubiquitination, as supported by the following evidence: 1) overexpression of USP2 stabilizes KRAS; 2) USP2 interacts with KRAS in cells as indicated by the immunoprecipitation and immunofluorescence assays; 3) USP2 directly removes ubiquitin from ubiquitylated KRAS, which leads to KRAS stabilization, whereas USP2 inhibition results in the proteasomal degradation of KRAS."
39807309
sparser
"Endogenous interaction of KRAS and USP2 was further verified in MM."
39807309