IndraLab

Statements

FGF12 binds SCN8A. 2 / 2
1 | 1
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
sparser
"When the arginine is mutated to histidine, the disturbance of inactivation of Nav1.6 that interacts with FGF12 occurs, leading to an influx of sodium influx increase, consequently elevating the neuron[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37331110