IndraLab

Statements

Modified TGFB1 increases the amount of FOXP3. 5 / 5
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"This unique coexpression of high levels of TGF-beta1, RALDH1, and RALDH2 in lung tissue MOs directly correlated with the intrinsic ability of these cells to induce Foxp3 expression (XREF_FIG)."
23547101
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"They also suggest that high levels of TGF-beta1 do not accelerate the early kinetics of FOXP3 expression, and the enhanced T reg cell differentiation seen in T reg hi conditions may reflect either stabilization of the FOXP3 + state and/or higher TGF-beta1 levels available at later timepoints to continue driving T reg cell differentiation."
25998054
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"Further analysis indicated that high-dose FDPGLM significantly increased the serum levels of TGF-beta1, which in turn promoted wound healing, upregulated the expression of the Foxp3 gene, and enhanced CD4 + CD25 + Foxp3 + Tregs differentiation, thereby facilitating immune regulation, inhibition of cellular immunity, and release of inflammatory cytokines."
29191190
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"Although TGF-beta1 is necessary for differentiation of pathogenic Th17 cells, recent studies indicate that heightened levels of TGF-beta1 induces increased levels of Foxp3, which reduces Th17 cell differentiation."
21311970
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"By using an autocrine mechanism T-cell specific transgenic TGFbeta1 overexpression leads to an increased frequency of CD4+ CD25+ cells and an overexpression of the Treg specific transcription factor Foxp3 in the thymus XREF_BIBR."
24339930