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USP15 deubiquitinates SMAD3 ubiquitinated on K81 on K81. 1 / 1
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"In contrast, USP15 deubiquitinates mono-ubiquitinated SMAD3 at K81 and to a lesser degree at K33 and K53 suggesting that USP15 deubiquitinates R-SMADs in the MH1 domain at sites independent of SMURF2 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"