IndraLab

Statements

UCHL1 decreases the amount of EGFR. 3 / 3
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"Knockdown of UCHL1 markedly reduced the protein levels of total EGFR and phosphorylated EGFR, AKT, and ERK1/2, with no effect on the EGFR mRNA level compared with the siRNA-controls after saline or PE stimulation."
32494592
reach
"These data imply that UCHL1 and KLF5 might act as upstream regulators of ERα expression in TNBC.Our qRT-PCR and western blotting results showed that UCHL1 knockdown decreased FGFBP1 (a known KLF5 transcriptional target gene [34]) and EGFR expression but increased ESR1 expression at both mRNA and protein levels (Fig. 2A-B, Supplementary Fig. 7)."
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reach
"Knockdown of UCHL1 significantly enhanced EGFR ubiquitination but decreased the EGFR level compared with the siRNA-control (XREF_FIG)."
32494592