IndraLab

Statements

PKC phosphorylates SCN5A. 7 / 7
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"Mutations causing loss of function of this enzyme, in turn, cause increased levels of glycerol-3-phosphate, promoting the protein kinase C dependent phosphorylation of the SCN5A."
28928611
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"GPD1L links redox state to cardiac excitability by PKC dependent phosphorylation of the sodium channel SCN5A."
19666841
sparser
"Valdivia et al. clarified the relationship between GPD1L and SCN5A: PKC-dependent phosphorylation of SCN5A leads to the connection of redox state and cardiac excitability through GPD1L ( xref )."
34277054
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"PKC-dependent phosphorylation of NaV1.5 at S1503 causes alterations in I Na kinetics that open up a window current [ xref ], and PKC inhibition blocked increased late I Na that was caused by calcium loading the cell [ xref ], suggesting the invovlement of PKC in CaM pathway causes of late I Na ."
26092781
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"This suggests that S1503 is the PKC phosphorylation site in SCN5A."
38653189
sparser
"Mutations causing loss of function of this enzyme, in turn, cause increased levels of glycerol-3-phosphate, promoting the protein kinase C-dependent phosphorylation of the SCN5A.[ xref ]"
28928611
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"They demonstrated association of GPD1L with SCN5A; mutants of GPD1L increased PKC mediated phosphorylation of SCN5A which in turn causes a dysfunction in sodium current, a mechanism for ventricular arrhythmias."
21685173