IndraLab

Statements

PKC phosphorylates SCN5A. 4 / 4
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"Mutations causing loss of function of this enzyme, in turn, cause increased levels of glycerol-3-phosphate, promoting the protein kinase C-dependent phosphorylation of the SCN5A.[ xref ]"
28928611
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"GPD1L links redox state to cardiac excitability by PKC dependent phosphorylation of the sodium channel SCN5A."
19666841
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"Mutations causing loss of function of this enzyme, in turn, cause increased levels of glycerol-3-phosphate, promoting the protein kinase C dependent phosphorylation of the SCN5A."
28928611
reach
"They demonstrated association of GPD1L with SCN5A; mutants of GPD1L increased PKC mediated phosphorylation of SCN5A which in turn causes a dysfunction in sodium current, a mechanism for ventricular arrhythmias."
21685173