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OTULIN bound to Nsp11 inhibits IRF3. 1 / 1

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"OTULIN is upregulated in a PRRSV infection model and interacts with the PRRSV non structural protein 11 (Nsp11) to decrease Ub levels on NEMO and to block NF-kappaB activation and IFN-regulatory transcription factor 3 (IRF3)-mediated type-I IFN production [XREF_BIBR]."

33288901

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IndraLab

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OTULIN bound to Nsp11 inhibits IRF3. 1 / 1

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