IndraLab

Statements

USP3 inhibits IL1. 6 / 6
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"For example, USP3 was deficient in OA and USP3 abundance suppressed IL-1β-induced chondrocyte apoptosis by targeting TRAF6 [6]."
37814350
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"USP3 upregulation attenuated IL-1β-mediated apoptosis of chondrocytes and inactivation of NF-κB pathway (107)."
37359559
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"Our results show that overexpression of USP3 could inhibits IL-1β-induced apoptosis, indicating that USP3 may be a negative regulator of OA development."
31056254
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"This study demonstrated that USP3 probably attenuated IL-1β-mediated chondrocyte senescence by deacetylating FOXO3 via SIRT3."
34847835
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"USP3 participates in the establishment of innate immune “tolerance” memory through a non-transcriptional feedback mechanism and negatively regulates TLR/IL1β-induced inflammatory signaling activation by specifically removing the K63-linked polyubiquitin chain on MyD88."
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"Ubiquitin-specific protease-3 (USP-3) attenuates IL-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via SIRT3 (61)."
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