IndraLab

Statements


GM inhibits CASP1. 2 / 2
| 2

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"Compared with the Control group, GL treatment had no effect on caspase-1 activity (P> 0.05), while ST infection significantly (P < 0.05) increased the activity of caspase-1, which could be significantly (P < 0.05) reversed by GL or GM pretreatments (XREF_FIG)."

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"In vitro, in nasal epithelial cells, LL37 stimulates inflammation and cell death; another GM compound, GM-0111, inhibits IL-6 and IL-8 release and blocks Caspase-1- and Caspase-8 -induced cell death (Thomas et al., 2017)."