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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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OTUB1 inhibits TP53BP1. 4 / 4

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"The depletion of OTUB1 results in persistent ubiquitin chain formation at DSB sites, and the overexpression of OTUB1 inhibits 53BP1 IRIF, suggesting that OTUB1 is involved in RNF8- and RNF168 dependent DDR."

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"Accordingly, the overexpression of OTUB1 inhibits K63 chain accumulation and 53BP1 IRIF."

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"Both OTUB1 and the catalytically inactive OTUB1 C91S mutant completely suppressed accumulation of 53BP1 at DSBs."

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"Depletion of OTUB1 leads to persistent 53BP1 after DNA damage ."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

OTUB1 inhibits TP53BP1. 4 / 4

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