IndraLab

Statements

Clozapine inhibits KCNH2. 7 / 7
4 | 3
tas
No evidence text available
15911273
reach
"For example, the blockade of HERG by clozapine (Lee et al., 2006) and trifluoperazine (Choi et al., 2005) resulted in IC 50 values 10- to 20-fold higher when the drug was applied to the Xenopus oocyte[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18191158
tas
No evidence text available
19534531
reach
"The IC (50) for the clozapine blockade of HERG currents in Xenopus oocytes progressively decreased relative to depolarization (39.9 microM at -40 mV, 28.3 microM at 0 mV and 22.9 microM at +40 mV), whereas the IC (50) for the clozapine induced blockade of HERG currents in HEK293 cells at 36 degrees C was 2.5 microM at +20 mV."
16633353
tas
No evidence text available
| DOI
reach
"Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine."
16633353
tas
No evidence text available
21185626