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Clozapine inhibits KCNH2. 3 / 7
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"Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine."
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"For example, the blockade of HERG by clozapine (Lee et al., 2006) and trifluoperazine (Choi et al., 2005) resulted in IC 50 values 10- to 20-fold higher when the drug was applied to the Xenopus oocyte[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The IC (50) for the clozapine blockade of HERG currents in Xenopus oocytes progressively decreased relative to depolarization (39.9 microM at -40 mV, 28.3 microM at 0 mV and 22.9 microM at +40 mV), whereas the IC (50) for the clozapine induced blockade of HERG currents in HEK293 cells at 36 degrees C was 2.5 microM at +20 mV."
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