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PKA phosphorylates KCNH2. 20 / 20
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"Here, we report that the PKA-RII-specific AKAP inhibitory peptide AKAP-IS perturbs the distribution of PKA-RII and diminishes the PKA dependent phosphorylation of HERG protein."
18679741
sparser
"Elevations of cAMP as seen in beta-adrenergic stimulation can result in PKA-dependent phosphorylation of hERG and direct binding of cAMP to the channel protein."
16050263
sparser
"HERG/ I Kr responds to acute adrenergic signaling in a complex fashion that includes direct cAMP binding to the channel, PKA-dependent phosphorylation of HERG and phosphorylation-dependent binding to the adaptor protein 14-3-3 (Choe et al. xref ; Kagan et al. xref ; Thomas et al. xref )."
18679741
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"By shifting the voltage gated activation to more depolarized potentials, PKA dependent phosphorylation of HERG renders the channel less likely to open during action-potential voltages."
10837251
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"HERG/I Kr responds to acute adrenergic signaling in a complex fashion that includes direct cAMP binding to the channel, PKA dependent phosphorylation of HERG and phosphorylation dependent binding to the adaptor protein 14-3-3."
18679741
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"Direct PKA phosphorylation of the HERG protein was responsible for the cAMP induced augmentation."
19234087
sparser
"14-3-3 accelerates and enhances HERG activation, an effect that requires PKA phosphorylation of HERG and dimerization of 14-3-3."
11953308
sparser
"PKA phosphorylation of HERG protein regulates the rate of channel synthesis."
19234087
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"Interestingly, a direct phosphorylation of the hERG cytoplasmic domains by PKA is involved in the regulation triggered by activation of beta-adrenergic receptors, and some signaling cross-talk between PKC and PKA can not be excluded."
22470342
sparser
"Interestingly, a direct phosphorylation of the hERG cytoplasmic domains by PKA is involved in the regulation triggered by activation of β-adrenergic receptors (Thomas et al., xref ; Cui et al., xref , xref ; Kiehn, xref ; Kagan et al., xref ; Karle et al., xref ), and some signaling cross-talk between PKC and PKA cannot be excluded."
22470342
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"Activation of cAMP dependent protein kinase (PKA) causes phosphorylation of HERG accompanied by a rapid reduction in current amplitude, acceleration of voltage dependent deactivation, and depolarizing shift in voltage dependent activation."
10837251
sparser
"Direct PKA phosphorylation of the HERG protein was responsible for the cAMP-induced augmentation."
19234087
sparser
"AKAP- IS Decreases PKA-Dependent Phosphorylation of HERG Channels."
18679741
reach
"Elevations of cAMP as seen in beta-adrenergic stimulation can result in PKA dependent phosphorylation of hERG and direct binding of cAMP to the channel protein."
16050263
reach
"AKAP-IS Decreases PKA Dependent Phosphorylation of HERG Channels."
18679741
sparser
"Here, we report that the PKA-RII-specific AKAP inhibitory peptide AKAP- IS perturbs the distribution of PKA-RII and diminishes the PKA-dependent phosphorylation of HERG protein."
18679741
sparser
"PKA directly phosphorylates HERG, producing an inhibition of current at all voltages, accelerated deactivation and a rightward shift in voltage dependence of activation."
10837251
reach
"14-3-3 accelerates and enhances HERG activation, an effect that requires PKA phosphorylation of HERG and dimerization of 14-3-3."
11953308
reach
"PKA dependent phosphorylation of hERG gives the channels a minor ability to open during action-potential voltages."
26431495
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"PKA phosphorylation of HERG protein regulates the rate of channel synthesis."
19234087