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PKA phosphorylates KCNH2. 21 / 26
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"Here, we report that the PKA-RII-specific AKAP inhibitory peptide AKAP- IS perturbs the distribution of PKA-RII and diminishes the PKA-dependent phosphorylation of HERG protein."
18679741
sparser
"HERG/ I Kr responds to acute adrenergic signaling in a complex fashion that includes direct cAMP binding to the channel, PKA-dependent phosphorylation of HERG and phosphorylation-dependent binding to the adaptor protein 14-3-3 (Choe et al. xref ; Kagan et al. xref ; Thomas et al. xref )."
18679741
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"AKAP- IS Decreases PKA-Dependent Phosphorylation of HERG Channels."
18679741
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"PKA directly phosphorylates HERG, producing an inhibition of current at all voltages, accelerated deactivation and a rightward shift in voltage dependence of activation."
10837251
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"Interestingly, a direct phosphorylation of the hERG cytoplasmic domains by PKA is involved in the regulation triggered by activation of β-adrenergic receptors (Thomas et al., xref ; Cui et al., xref , xref ; Kiehn, xref ; Kagan et al., xref ; Karle et al., xref ), and some signaling cross-talk between PKC and PKA cannot be excluded."
22470342
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"PKA phosphorylation of HERG protein regulates the rate of channel synthesis."
19234087
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"Direct PKA phosphorylation of the HERG protein was responsible for the cAMP induced augmentation."
19234087
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"Interestingly, a direct phosphorylation of the hERG cytoplasmic domains by PKA is involved in the regulation triggered by activation of beta-adrenergic receptors, and some signaling cross-talk between PKC and PKA can not be excluded."
22470342
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"Initially, stimulation of β-AR triggers the phosphorylation of HERG channel by PKA, which together with cAMP direct interaction with an intracellular CNBD (Cyclic Nucleotide Binding Domain) of the cha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23811359
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"14-3-3 accelerates and enhances HERG activation, an effect that requires PKA phosphorylation of HERG and dimerization of 14-3-3."
11953308
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"14-3-3 accelerates and enhances HERG activation, an effect that requires PKA phosphorylation of HERG and dimerization of 14-3-3."
11953308
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"Elevations of cAMP as seen in beta-adrenergic stimulation can result in PKA dependent phosphorylation of hERG and direct binding of cAMP to the channel protein."
16050263
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"By shifting the voltage gated activation to more depolarized potentials, PKA dependent phosphorylation of HERG renders the channel less likely to open during action-potential voltages."
10837251
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"PKA then phosphorylates hERG channels and reduces their ability to open during action potentials, therefore decreasing I ."
35718417
sparser
"Direct PKA phosphorylation of the HERG protein was responsible for the cAMP-induced augmentation."
19234087
reach
"PKA phosphorylation of HERG protein regulates the rate of channel synthesis."
19234087
reach
"Here, we report that the PKA-RII-specific AKAP inhibitory peptide AKAP-IS perturbs the distribution of PKA-RII and diminishes the PKA dependent phosphorylation of HERG protein."
18679741
reach
"PKA dependent phosphorylation of hERG gives the channels a minor ability to open during action-potential voltages."
26431495
reach
"HERG/I Kr responds to acute adrenergic signaling in a complex fashion that includes direct cAMP binding to the channel, PKA dependent phosphorylation of HERG and phosphorylation dependent binding to the adaptor protein 14-3-3."
18679741
reach
"AKAP-IS Decreases PKA Dependent Phosphorylation of HERG Channels."
18679741
sparser
"Elevations of cAMP as seen in beta-adrenergic stimulation can result in PKA-dependent phosphorylation of hERG and direct binding of cAMP to the channel protein."
16050263