IndraLab

Statements

Parathion inhibits TLR7. 5 / 5
| 5
reach
"Although the inhibitory effect of select LNA and DNA AMOs was surprising, it is consistent with a previous report that phosphorothioate DNA oligonucleotides can inhibit TLR7 sensing in a sequence dependent manner."
25539920
reach
"Such miRNA independent TLR7 inhibition by these LNA and DNA phosphorothioate AMOs is rather in line with previous studies that reported the specific inhibition of R848 and immunostimulatory ssRNA driven TLR7 activation, by phosphorothioate DNA oligonucleotide (ODN) in human HEK293 TLR7 cells and in mouse splenocytes."
25539920
reach
"However, an RNA dependent TLR7 IFN-alpha cytokine release is suppressed by the phosphorothioate DNA sequence contained in the chimeric molecule."
22196370
reach
"Peripheral blood mononuclear cells (PBMC) and peripheral lymph node cell suspensions from healthy SIV-naive macaques were incubated with aldrithiol-2-inactivated SIVmac239 particles (iSIV) or influenza virus in the presence or absence of DV056, a 25 based single stranded phosphorothioate oligodeoxynucleotide antagonist of TLR7 and TLR9 that contains the necessary inhibitory motifs with optimization for activity in nonhuman primates and humans XREF_BIBR."
23935491
reach
"We establish that this effect relies on an inhibitory motif present in more than 50 miRNA AMOs, and that LNA and DNA phosphorothioate AMOs can also inhibit TLR7 in a sequence dependent manner."
25539920