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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PSMD14 activates IL1B. 2 / 2

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"Unexpectedly, upon treatment with the inflammasome activators, POH1 deficiency did not lead to an increase in pro-caspase-1 cleavage in LPS primed BMDMs, but enhanced cleavage of pro-IL-1beta, as measured by the mature forms of pro-caspase-1 and pro-IL-1beta."

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"POH1 deficiency in macrophages enhances mature IL-1beta production without significant alterations in inflammasome priming and ASC-caspase-1 activation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...