IndraLab

Statements

ATXN3 decreases the amount of PTEN. 8 / 8
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"A recent study reported that Ataxin-3 repressed the expression of PTEN."
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"Mechanically, Ataxin-3 inhibits the phosphatase and tensions homolog (PTEN) expression and then activates the AKT/mTOR pathway."
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"52 Furthermore, ATXN3 upregulation inhibited the expression of PTEN and triggered the AKT/mTOR pathway."
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"The results showed that Ataxin-3 inhibited the expression of PTEN, which is consistent with the finding of previously studies [ 12 ]."
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"Indeed, HAUSP/USP7, Ataxin-3, USP10, USP11, USP13, and OTUD3 have all been identified as PTEN DUBs; HAUSP specifically removes monoubiquitin from PTEN to promote its nuclear export ; Ataxin-3 restricts PTEN transcription ; and USP10, USP11, USP13 and OTUD3 increase PTEN stability in different cancer-specific contexts ."
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"A small interfering RNA (siRNA) screen for deubiquitinases revealed that three MJD subfamily members, including Ataxin-3, can inhibit PTEN expression ."
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"The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells."
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"Moreover, a recent study by Coulson and colleagues 46 provided convincing evidence that ataxin-3 restricts the transcription of the tumor suppressor PTEN."
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