IndraLab

Statements

UCHL1 increases the amount of SNCA. 3 / 3
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"In this line, in vitro studies using a crude cell-free system where alpha-synuclein was conjugated to histidine tagged ubiquitin revealed that the addition of UCHL-3 had little effect, whereas the add[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Reduction of UCH-L1 (M) in cell culture models of alpha-synuclein toxicity by treatment with a farnesyltransferase inhibitor (FTI-277) reduces alpha-synuclein levels and increases cell viability."
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"Chemical inhibition of UCHL1 by farnesylation may reduce alpha-synuclein levels and improve neuronal cell viability in cellular models of alpha-synuclein-associated toxicity for PD."
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