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LY294002 inhibits NFKBIA. 3 / 4
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"Additionally, LY294002, AKT-shRNA and IkappaBalpha-shRNA could decrease the protein content of phospho-IkappaBalpha and phospho-IKKbeta in STC1 overexpressed HeLa and CaSki cells compared with the control cells."
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"Although the oleate activated AKT, IkappaBalpha and ERK were inhibited by LY294002, parthenolide and U0126, respectively, only LY294002 and parthenolide significantly inhibited the oleate induced PTX3 expression."
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"Akt has been shown to phosphorylate IkappaBalpha and induce its degradation, however LY294002 treatment only further enhanced the degradation of IkappaBalpha induced by LMP1 (XREF_FIG)."
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