IndraLab

Statements

Cilostazol inhibits NLRP3. 5 / 5
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"Compared with the DCM group, 15 mg/kg Cilostazol and 30 mg/kg Cilostazol could significantly decrease TXNIP, NLRP3, and cleaved Caspase-1 levels (p < 0.05)."
38233884
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"Meanwhile, Cilostazol could significantly decrease TXNIP, NLRP3, and cleaved Caspase-1 levels."
38233884
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"We found that cilostazol significantly reduced NLRP3 inflammasome activation, as well as the activity of other related and harmful factors, including oxidative stress, expression of NADPH oxidase 4 (NOX-4), thioredoxin interacting protein (TxNIP), high mobility group box 1 (HMGB-1), interleukin 1beta (IL-1beta) and IL-18."
31514535
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"254 Cilostazol could inhibit the activation of NLRP3 inflammasome in endothelial cells, thereby inhibiting the production of IL‐1β and IL‐18, suggesting it could reduce adverse vascular reactions and treat endothelial dysfunction in DM patients."
38617433
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"Cilostazol significantly reduces NLRP3 inflammasome activation and the activity of NOX4, TXNIP, HMGB1, IL-1beta, and IL-18 in HAECs induced with FFA."
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