IndraLab

Statements

KCN inhibits KCNH1. 3 / 3
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"Inhibition of Kv10.1 by the potassium channel blocker astemizole, the specific anti-Kv10.1 antibody mAb56, or siRNA strongly increased apoptosis in primary AML cells and cell lines treated with chemotherapeutic agents commonly used in AML therapy, including etoposide, cytarabine, and doxorubicin [ xref ]."
35207698
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"A possible role of hEag1 in leukemia cell proliferation could be shown by growth and migration inhibition of the hEag1 expressing cell lines PLB-985, K562, UT-7 and HEL and primary clinical samples by the potassium channel blockers astemizole, imipramine, the hEag1 specific monoclonal antibody mAb56 and siRNA knockdown [XREF_BIBR]."
20105281
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"In addition, a cluster of potassium channel proteins were downregulated: KCND2, KCNH1, KCNJ9, and KCNT1."
33942443