IndraLab

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"To test this possibility, we first examined whether USP19 would bind with RORγt under pTh17 polarizing conditions."

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"The interaction between USP19 and RORγt in pTh17 cells was validated by co-immunoprecipitation (co-IP) ( xref )."

No evidence text available

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"Although our results clearly demonstrate that USP19 interacts directly with RORγt and constrains pathogenic Th17 cell programming and response amplification, deubiquitinases also have effects on multiple other substrates."