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USP22 leads to the acetylation of TP53. 3 / 3
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"The USP22-mediated accumulation of SIRT1 inhibits p53 acetylation and its transcriptional activity."
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"Collectively, our data indicates that USP22 inhibits p53 functions through Sirt1 deacetylase.To further prove that USP22 acts on p53 by stabilizing Sirt1, we tested whether inactivation of USP22 incre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, USP22 suppresses p53 transcriptional activity and proapoptotic functions.Our finding that USP22 inhibits the p53 transcriptional activity and stabilizes Sirt1 suggests that USP22 inhibits p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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